Caine occurs as fictional character, the father of a lot vampires in White Wolf Game Studio's role-playing games set in the World of Darkness. His story is according to a biblical story of Cain, and is recounted in the Book of Nod.

Caine & Abel were asked by God to present a sacrifice of that which it virtually all cared for. Caine chose to obliterate Abel, his dear brother, when a offering requested by God. For this he was exiled to the Land of Nod. He was taken within by Lilith, Adam's first married woman, & taught to exist as self-self-sufficing.

He so became chesty & 3 days refused salvation & forgiveness, offered by archangels speaking on behalf of God, saying that by his have grace, & non God's, he would receive salvation. A archangels cursed him three separate days for his pride, returning him the powers & weaknesses of the lamia. Specifically, he received fear of flame from the archangel Michael, vulnerability to sunlight from the archangel Raphael, and immortality, along with a inability for even him or his tikes to sustain themselves in anything however vitae (blood), from a archangel Uriel.

Caine got 3 childer, which in turn produced 13 of their have (a Antediluvian founders of the major vampiric clans).

Around Vampire: The Dark Ages, the followers of the Cainite Heresy believed that Caine would return as a vampiric messiah.

Inside Vampire: The Masquerade, the system for combat Caine come elementary. All the book states is: "You lose".